Dual targeting PD-1 and BRD4 with INTASYL self-delivering RNAi elicits persistent anti-tumor immunity in-vivo following complete resolution of tumors.
Annals of Oncology, 2021, Volume 32, Supplement 5. 10.1016/j.annonc.2021.08.1735. Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Brianna Rivest, James Cardia and Simon P. Fricker.
Targeting BRD4 in T cells with self-delivering RNAi PH-894 for immunotherapy.
Molecular Cancer Therapeutics, 2021, Volume 20, Issue 12 Supplement. 10.1158/1535-7163.TARG-21-P109. Melissa Maxwell, Daisuke Ujiie, Benjamin Cuiffo, Brianna Rivest, Dingxue Yan, James Cardia, Jeroen Melief, Rolf Kiessling, and Simon P. Fricker.
Locally administered immunotherapy self-delivering RNAi PH-762 results in abscopal clearance of untreated distal tumors, suggesting systemic immune response, in a murine hepatocarcinoma model.
Journal for ImmunoTherapy of Cancer, 2021, Volume 9, Issue Supplement 2. 10.1136/jitc-2021-SITC2021.869. Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Brianna Rivest, James Cardia and Simon Fricker.
INTASYL™ self-delivering RNAi therapy specifically dual-targeting BRD4 and PD-1 elicits complete tumor responses and evidence of synergy in a subcutaneous Hepa1-6 model of murine hepatoma in C57BL/6N mice.
Journal of Clinical Oncology, 2021, Volume 39, Supplement 15. 10.1200/JCO.2021.39.15_suppl.e14537. Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Brianna Rivest, James Cardia and Simon P. Fricker.
INTASYL™ PH-762 self-delivering RNAi targeting PD-1 enhances the therapeutic efficacy of systemically administered HER2-targeted CAR-T cells in a SKOV3 model of human ovarian adenocarcinoma in NCG mice.
Molecular Therapy, 2021, Volume 29, Issue 4, Supplement 1. 10.1016/j.ymthe.2021.04.019. Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Brianna Rivest, James Cardia and Simon P. Fricker.
Intratumoral INTASYL™ self-delivering RNAi targeting PD-1 provides in vivo tumor control and mechanistic modulation of tumor microenvironment analogous to that of systemic anti-PD-1 antibody.
Cancer Research,Volume81, Issue 13 Supplement. 10.1158/1538-7445.AM2021-1739 Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, James Cardia and Simon P. Fricker.
Combination intratumoral treatment with INTASYL™ self-delivering RNAi targeting TIGIT and PD-1/PD-L1 improves tumor control compared to monotherapy in a subcutaneous CT26 model of murine colorectal cancer.
Journal for ImmunoTherapy of Cancer, 2020, Volume 8, Supplement 3. 10.1136/jitc-2020-SITC2020.0198 Benjamin Cuiffo, Melissa Maxwell, Dingxue Yan, Andrej Jedinak, James Cardia and Simon P. Fricker.
Intratumoral delivery of mPH-804 (TIGIT targeting INTASYL™ compound) inhibits tumor growth and confers an inflammatory tumor microenvironment.
Cancer Research, 2020, Volume 80, Issue 16 Supplement. 10.1158/1538-7445.AM2020-2239 Simon P. Fricker, Andrej Jedinak, Melissa Maxwell, Mani Kadiyala, Dingxue Yan, James Cardia and Gerrit Dispersyn.
Intratumoral use of self-delivering RNAi to reprogram the tumor microenvironment and boost the antitumor response.
Journal of Clinical Oncology, 2020, Volume 38, Issue 15 Supplement. 10.1200/jco.2020.38.15_suppl.e15206. Gerrit Dispersyn, Sribalaj Lakshmikanthan, Dingxue Yan, Andrej Jedinak, Melissa Maxwell, Mani Kadiyala, James Cardia and …
Adoptive Cell Therapy don’t over engineer it: Alternatives to gene editing to improve cell-based therapeutics for the treatment of cancer.
Molecular Therapy, 2020, Volume 28, No 4, Supplement 1. 10.1016/j.ymthe.2020.04.019. Simon P. Fricker, Melissa Maxwell, Mani Kadiyala, James Cardia and Gerrit Dispersyn.
Local modulation of T cell PD-1 using self-delivering RNAi as a potential immunotherapeutic.
Journal for ImmunoTherapy of Cancer, 2019, Volume 7. 10.1186/s40425-019-0764-0 Melissa Maxwell, Mani Kadiyala, Dingxue Yan, Winnie Tam, John Barrett, James Cardia, Simon Fricker and Gerrit Dispersyn.
Modulating BRD4 in T cells using self-delivery RNAi to improve adoptive cell therapy of cancer.
Journal for ImmunoTherapy of Cancer, 2019, Volume 7. 10.1186/s40425-019-0763-1 Jeroen Melief, Laura L. Van Leeuwe Kirsch, Esmeralda Hemme, John A. Barrett, Simon P. Fricker, Gerrit Dispersyn and …
Feasibility and efficacy of using self-delivering RNAi against TGF-β1 to reduce TME immunosuppression
Cancer Research, 2019, Volume 79, Issue 13 Supplement. 10.1158/1538-7445.AM2019-1963 Winnie Tam, Dingxue Yan, Melissa Maxwell, James Cardia and Gerrit Dispersyn.
Self-delivering RNA interference targeting PD-1 improves tumor specific T cell functionality for adoptive cell therapy of malignant melanoma.
Molecular Therapy,2018, Volume 26, Issue 6. 10.1016/j.ymthe.2018.04.015. Maarten A. Ligtenberg, Yago Pico de Coaña, Taisia Shmushkovich, Yuya Yoshimoto, Iva Truxova, Yuan Yang, Monica Betancur-Boissel, Alexey …
Visualization of self-delivering hydrophobically modified siRNA cellular internalization.
Nucleic Acids Research, 2017, Vol. 45, No. 1: 15 -25. 10.1093/nar/gkw1005. Socheata Ly, Deanna M. Navaroli, Marie-C´ ecile Didiot, James Cardia, Lakshmipathi Pandarinathan, Julia F. …